What Are the Main Uses of GC Vials?

Do you have a business that requires regular experiments? Perhaps you handle a lot of chemicals and have production lines ready to go? Maybe you aspire to be one of the 12 leading companies in clinical laboratories?  

If so, then you’ll probably be interested in GC vials as well as what they can do for your business. 

A GC vial can protect the chemicals you are trying to mix and can make sure they are stored in perfect condition until they are ready to be brought out of your lab.

So what are the main uses of GC vials and how can you use them in your business effectively? Here’s everything you need to know.

Avoiding Contamination 

Metals on the surface of these vials can contaminate, precipitate, chelate, or otherwise alter samples.

During the production of RSA, these common metals, commonly found in other borosilicate glass vials, are removed and thus prevent adducts from forming when using an LCMS autosampler. Glass, vials, and glass inserts that they produce uncoated.

When handling sensitive compounds use the RSA autosampler vials, as the glass wall of conventional vials can interact with the base compounds.

Try reaching out to for more information about GC vials.

When using different commercially available borosilicate glasses, tubes, and inserts for autosamplers; sample diluents (eg water) can deprotonate numerous hydroxyl groups on the surface of the vial, creating a negative charge on the glass.     


After the sample phase has been introduced into the vial and the vial is sealed, the volatiles diffuses into the gas phase, also known as gas chromatography. The headspace above the product reaches equilibrium.

You should use RSA autosampler vials to lower the content base samples and use regular glass vials. Some of your compounds can likely be easily absorbed by the glass wall.     

Changes in the composition of the headspace gas, such as whether there is a large amount of solvent in the sample compared with the standard, will affect the flow rate of the sample gas from the tube directly to the chromatographic column or through the sampling loop and restrictor.

A longer sampling interval results in a lower circuit pressure, which in turn results in a smaller injection peak area because more and more headspace gas is released into the environment.

Six-Port Injection Valve 

The six-port injection valve selects whether the sample flows from the sample bottle or the carrier gas to the chromatographic column through the injection loop.

Most applications directly use carrier gas for pressurization, although in some cases an independent gas source can be used for pressurization and transmission, such as when the carrier gas inlet pressure is too high to withstand the influence of headspace bubbles or baffles, or when the split inlet is equipped with a separate flow regulator.     

Short Delay 

A short delay in pressure build-up before transferring the sample from the vial allows the injected gas to mix completely with the headspace gaseous content.

As a practical guide, use a vial large enough to provide sufficient headspace or phase ratio without over-diluting the interest. Autosampler vials can be widely used in HPLC and GC, and although they are widely used consumables, high quality is important to ensure zero contamination in the final chromatographic separation.

This product can be used as a high sensitivity test vial in standard lc as well as in lc/ms and GC / ms analyzes.     

Static Headspace  

In static headspace analysis, it is also important to know the time required to balance the vapor pressure, which can vary between connections and is highly dependent on the viscosity of the sample.     

Thus, users can use the product with confidence without worrying about phantom peaks emanating from the vial. Most of this pressure is generated by the vapor solvent. Pressure a few sample vials have limited absorbance, but the results show poor reproducibility stability. Using certified, application-oriented, contaminant-free vials can significantly reduce risk.     

For example, the volume of the vessel for the headspace should not be too large compared to the volume of the sample to avoid the complete vaporization of the component into the gas phase. Gas chromatography over vapor is a sampling technique. 

It consists of the determination of volatiles in liquid or solid samples. These are analyzed with the vapor phase in thermodynamic equilibrium.

Verifying Accuracy 

In addition, the technician can use a blank (which contains no detectable compounds) to verify the accuracy of the GC / ms instrument data representation.     

This misinformation from the various surfaces of the glass vials can lead to incorrect research or decision-making. The volatile nature reduces the need to clean and maintain the inlet, column, and detector, reducing instrument downtime. This method has limited experimental application due to the risk of rupture of the sample container.      

If this happens, the GC vial instrument will offer some results. It indicates the presence of this unexpected reaction product instead of the starting compound present in the GC sample vials.

If the instrument uses hydrogen as the carrier gas, the technician should consider whether the hydrogen will react with any compounds in the sample.     

Sufficient Heating 

And with sufficient heating, the stability of the size of the bottle will be questionable. The final choice of carrier gas may depend on the detector used with the GC autosampler vials. 

The technician might measure the retention time from sample injection to compound elution from the column. Equipment used for gas chromatography typically has an injection port at one end of a metal column filled with support material. It also has a detector at the other end of the column. 

GC Vials Have Many Uses 

GC vials have many uses for your business. They can help you make sure the chemicals you are mixing are accurate and safe. They can also help you avoid contamination. 

If you have a business and are considering which type of vials to get, then it is well worth considering GC vials. 

For more, be sure to check out the rest of our site. 

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